Increased television watching may be a risk factor for coronary artery disease (CAD), according to a series of genetic and observational analyses reported in Nature Communications this week. Sedentary leisure activities have been associated with a higher risk of cardiovascular dis…
2020-06-22
NEW YORK – Broad Institute researchers have developed a CRISPR -based molecular diagnostics platform using microfluidics chips for the detection of viruses in human samples. A single chip has the capacity to detect a single virus in more than 1,000 samples at a time or to search…
2020-06-19A Korean team describes the use of target-mismatched single guide RNA (sgRNA) sequences to do CRISPR-Cas9-based microbial genome editing. Using the Escherichia coli model system, the researchers attempted to introduce changes in the galK gene. While their initial experiments sugge…
2020-06-18NEW YORK – Genetic engineering company Sherlock Biosciences said on Thursday that it has received Emergency Use Authorization from the US Food and Drug Administration for its Sherlock CRISPR SARS-CoV-2 kit for the detection of the virus that causes COVID-19. The test, which the …
2020-06-17The US Food and Drug Administration has issued an Emergency Use Authorization for a CRISPR-based test for SARS-CoV-2, as GenomeWeb reports. The test from Sherlock Biosciences relies on its Specific High-sensitivity Enzymatic Reporter unLOCKing platform, known as SHERLOCK. Accordin…
2020-06-15Stanford and Duke University researchers propose a CRISPR-Cas13-based strategy called "prophylactic antiviral CRISPR in human cells" (PAC-MAN) for combating influenza A viruses and coronaviruses such as SARS-CoV-2. The approach relies on RNA-guided inhibition and breakdown of the …
2020-06-11Editor's Note: Some of the articles described below are not yet available at the PNAS site, but they are scheduled to be posted some time this week. In the Proceedings of the National Academy of Sciences this week, a University of Texas Southwestern Medical Center-led team shares …
2020-06-10
NEW YORK – Three separate research teams have developed dual-deaminase CRISPR base editing platforms that combine the abilities of current adenine and cytosine base editors (ABEs and CBEs) to allow for concurrent A-to-G and C-to-T edits. In papers published on Monday in Nature B…
2020-06-09A team from Russia, China, Germany, and elsewhere share results from single-cell RNA sequencing- and bulk RNA-seq-based analyses of gene expression in samples from different brain regions in hundreds of humans, chimpanzees, bonobos, and rhesus macaques. With data on 33 anatomical …
2020-06-08
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